For Q-Hybrid and Physical backup jobs, the front end UI will not allow you to un-select a specific drive to exclude it from a backup job.  This because the UI displays disk drives in, while Q-Hybrid actually works on NTFS volumes.  Since you can have multiple volumes on a single drive, this regular front end exclusion process just won’t work.

However, you can still exclude your volumes from a Q-Hybrid or Physical backup based on the drive letter.  To do this, simply create a file called “exclusions.conf” in the C:\Windows\QSI\ folder on your target system.  In this file, simply place the drive letters you wish to exclude, separated by a space.

For example, if you wish to only protect your C:\, the contents of your exclusions.conf file would look like this:

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These exclusions are processed by Alike prior to each backup, so they can be changed at any time if you wish to include/exclude more volumes.